Metabolic and Inflammatory Disorders-Main Influencers of Psoriatic Arthritis Activity

Background: Psoriatic arthritis is a systemic, potentially severe condition associated with multiple comorbidities. It is characterized by peripheral and axial joint involvement, enthesitis, and association with various comorbidities.

Objective: This study aims to identify some of the determinants of the severity of psoriatic arthritis. We studied the prevalence and common pathogenic mechanisms of various comorbidities associated with PsA.

Methods: We studied 103 patients diagnosed with psoriatic arthritis. 69 met the inclusion criteria. We evaluated the disease activity index DAPSA, ESH, CRP, BMI, uric acid, cholesterol, triglycerides. Disease duration and type of joint involvement were also included.

Results: The patients in the studied group had an average age of 54.75 (sd±10.02) years and there were 36 (55.38%) women. Duration of the diseases 8.254 (sd±5.307) years and an average of DAPSA values of 20.58 (sd±8.522).

Clinical manifestations: 37 (56.92%) had peripheral damage; 6 (9.23%) had axial damage and 22 (33.85%) had mixed axial and peripheral damage. Inflammatory markers: ESR with an average serum value of 39.55 (sd±26.43) mm/h and average CRP values of 17.69mg/L (sd±28.71). The body mass index-an average value of 29.69Kg/m² (sd±5.979).

Biological markers: uric acid with an average serum value of 9.832 mg/dl (sd±2.089), triglycerides 262.6 mg/dl (sd±41.58) and cholesterol 319.8mg/dl (sd±56.14).

Conclusions: Serum levels of uric acid, cholesterol, triglycerides, ESR, and CRP influence psoriatic arthritis activity and response to treatment.